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In a year-long clinical trial, 5% of patches fully detached.

Check Twirla daily and after water exposure to make sure the edges haven’t lifted.

Meet Twirla®

Meet Twirla

Birth control designed to fit your life

Weekly. Self-administered. Just 3 patches a month.

Twirla is a hormonal birth control patch for women with a body mass index (BMI) less than 30 kg/m2 who can become pregnant. Twirla is less effective in women with a BMI of 25 kg/m2 or more to less than 30 kg/m2. Do not use if your BMI is 30 kg/m2 or more.

The hormone combination in Twirla has a long history of use in birth control pills.

Same-Time-Every-Day Pill or Weekly Patch

Which birth control method fits your life?


You know the daily pill routine: stop and take it every day, ideally at the same time each day for at least 21 days each month.


With Twirla, you change your patch just once a week for 3 weeks of your cycle. During the fourth week of your cycle, you wear no patch and should expect your period.

In a clinical trial, Twirla was 95% effective in preventing pregnancy.

The most common side effects reported by women using Twirla in a clinical study were skin reactions at the patch site, nausea, headache, menstrual cramps, and weight gain. These are not all the possible side effects of Twirla. 
Call your healthcare provider for medical advice about side effects.

Use Twirla


Purposefully designed—and proven—to stay in place.

Only Twirla uses Skinfusion® patch technology for consistent drug delivery and to help maintain adhesion. Twirla is made with a soft, flexible fabric designed to contour with a woman’s body.

In a large clinical trial, 95% of the 55,900 Twirla patches adhered.*

*In the trial, subjects reported better adhesion on the abdomen than on the upper torso or buttock. Five percent of patches fully detached. Full detachments occurred more frequently for patches exposed to water.


To prevent pregnancy, Twirla needs to remain adhered to the skin for 7 days. Check it daily and after any water exposure to ensure the edges haven’t lifted. Avoid prolonged water exposure (swimming or contact with water often or for long periods of time—30 minutes or more) or the use of makeup, creams, lotions, oils, powders, or any other products on the skin area where you put or plan to put the patch.

Is Twirla right for you?

Making a decision about which birth control is right for you starts with a conversation.

Twirla may not be appropriate for everyone. To find out if Twirla is right for you, you’ll need to talk to your doctor.



  • Do not use TWIRLA if you smoke cigarettes and are over 35 years old. Smoking increases your risk of serious cardiovascular side effects from combination hormonal contraceptives (CHCs), including death from heart attack, blood clots or stroke. This risk increases with age and the number of cigarettes you smoke.
  • Do not use TWIRLA if your body mass index (BMI) is 30 kg/m2 or more. If you do not know what your BMI is, please talk to your healthcare provider. Women with a BMI of 30 kg/m2 or more who use CHCs may have a higher risk for developing side effects like blood clots compared to women with a BMI lower than 30 kg/m2.

Who should not use TWIRLA?

Do not use TWIRLA if you have or have had blood clots; history of heart attack or stroke, high blood pressure that medicine cannot control, any condition that makes your blood clot more than normal, or certain heart valve problems; smoke and are over 35 years old; BMI ≥ 30 kg/m2.

TWIRLA is also not for women who have diabetes and are over 35 years old, diabetes with high blood pressure or kidney, eye, nerve, or blood vessel damage, diabetes for longer than 20 years; have had breast cancer or any cancer that is sensitive to female hormones; certain kinds of severe migraine headaches; have liver problems or liver tumors; unexplained bleeding from the vagina; who are or may be pregnant; or who take hepatitis C drugs containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, as this may increase levels of liver enzymes in the blood.

TWIRLA may not be a good choice for you if you have ever had depression; jaundice (yellowing of the skin or eyes) caused by pregnancy (also called cholestasis of pregnancy) or related to previous use of hormonal birth control.

What are the most serious side effects of TWIRLA?

TWIRLA increases the risks of serious side effects, including blood clots, stroke, or heart attack especially in women who have other risk factors. These can be life-threatening or lead to permanent disability. This increased risk is highest when you first start using hormonal birth control and when you restart the same or different hormonal birth control after not using it for a month or more. Treatment with TWIRLA should be stopped at least 4 weeks before and through 2 weeks after major surgery.

What are the most common side effects of TWIRLA?

The most common side effects reported by women using TWIRLA in a study were skin reactions at the patch site, nausea, headache, menstrual cramps, and weight gain.

These are not all the possible side effects of TWIRLA. Call your healthcare provider for medical advice about side effects.

You may report side effects to FDA at 1-800-FDA-1088 or at

What else should I know about TWIRLA?

TWIRLA is a birth control patch for women with a BMI less than 30 kg/m2 who can become pregnant. It contains two female hormones, a progestin called levonorgestrel, and an estrogen called ethinyl estradiol. TWIRLA may not be as effective in women with a BMI of 25 kg/m2 or more. If you have a BMI of 30 kg/m2 or more, please talk with your health care provider about which method of birth control is right for you.

You should not use TWIRLA any earlier than 4 weeks after having a baby or if you are breastfeeding.

Hormonal birth control methods help to lower the chances of becoming pregnant when taken as directed. They do not protect against HIV infection (AIDS) and other sexually transmitted infections (STIs).

The risk information provided here is not complete. To learn more, review the TWIRLA Patient Information and talk with your healthcare provider or pharmacist.