Twirla® may be applied to one of the following locations on the skin:

    SOME TWIRLA USE GUIDELINES

  • Twirla should be applied to clean, dry, and intact skin at the selected application site

  • Twirla should not be applied directly over the previous application site

  • Patients should not place the patch on their waistline or near clothing or undergarment seams

  • Patients should not apply Twirla to skin that has been exposed to powder, oil, moisturizer, or lotion. Advise women not to routinely use body lotions or oils at application sites

  • Advise women to check the patch for partial or complete detachment daily and after prolonged water exposure

  • Prolonged water exposure (30 minutes or more) may interfere with adhesion of Twirla



These are not full instructions for use. For more information on how your patients should apply Twirla and how to manage partial or complete detachments, see the product’s Patient Information Guide.




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IMPORTANT SAFETY INFORMATION

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WARNING: CIGARETTE SMOKING AND SERIOUS CARDIOVASCULAR EVENTS and CONTRAINDICATED IN WOMEN WITH A BMI ≥30 kg/m2

Cigarette Smoking and Serious Cardiovascular Events
Cigarette smoking increases the risk of serious cardiovascular events from combined hormonal contraceptive (CHC) use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, CHCs, including TWIRLA, are contraindicated in women who are over 35 years of age and smoke.
Contraindicated in Women with a BMI ≥30 kg/m2
TWIRLA is contraindicated in women with a BMI ≥30 kg/m2. Compared to women with a lower BMI, women with a BMI ≥30 kg/m2 had reduced effectiveness and may have a higher risk for venous thromboembolic events (VTEs).